Midazolam and Hydroxyzine Interaction
Drug interaction information between Midazolam and Hydroxyzine.
Midazolam and Hydroxyzine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Midazolam and Hydroxyzine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There are no known harmful effects when these two medications are used at the same time.
FDA Label Information
No significant adverse interactions with commonly used premedications or drugs used during anesthesia and surgery (including atropine, scopolamine, glycopyrrolate, diazepam, hydroxyzine, d-tubocurarine, succinylcholine and other nondepolarizing muscle relaxants) or topical local anesthetics (including lidocaine, dyclonine HCl and Cetacaine) have been observed in adults or pediatric patients.
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Midazolam + Hydroxyzine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Midazolam has 39 labeled pairs on file vs Hydroxyzine's 1. In the minor band specifically: Midazolam has 27 (also Nifedipine, Morphine, Diazepam, Atropine); Hydroxyzine has 1.
What mechanism field is on file for Midazolam and Hydroxyzine?
There are no known harmful effects when these two medications are used at the same time.
Midazolam carries more major-labeled pairs than Hydroxyzine
SPL source-record counts only. This page's band is minor · classes on file: Midazolam (Benzodiazepine); Hydroxyzine (Antihistamine / Anxiolytic).
Midazolam has 3 major-labeled pairs vs Hydroxyzine's 0. This page itself is in the minor band, not the major band.
3 major · 9 moderate · 27 minor · 39 total
- Other minor peers for Midazolam
- Nifedipine
- Morphine
- Diazepam
- Atropine
0 major · 0 moderate · 1 minor · 1 total
Hydroxyzine has no other minor-band peer in this dataset besides Midazolam.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.