What the FDA labels say about taking them together
Diazepam and omeprazole
Diazepam's FDA label of August 11, 2026 names omeprazole in its drug interactions section, and omeprazole's label names diazepam too. The omeprazole label: “Increased exposure of diazepam.”
Check it at the source: the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the diazepam label say about omeprazole?
Diazepam label, drug interactionsAt present, this reaction is known to occur with cimetidine, ketoconazole, fluvoxamine, fluoxetine, and omeprazole.
Valtoco label (Neurelis, Inc, June 3, 2026), drug interactionsMetabolism of Other Drugs Diazepam is a substrate for CYP2C19 and CYP3A4; therefore, it is possible that VALTOCO may interfere with the metabolism of drugs which are substrates for CYP2C19 (e.g., omeprazole, propranolol, and imipramine) and CYP3A4 (e.g., cyclosporine, paclitaxel, theophylline, and warfarin) leading to a potential drug-drug interaction.
Source: FDA drug label (Valtoco, NDA211635), Neurelis, Inc, effective June 3, 2026 (SPL set 1a8bcc90-68fa-474d-832c-0df01e825f39), via openFDA
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
What does the omeprazole label say about diazepam?
Omeprazole label, drug interactionsDiazepam Clinical Impact: Increased exposure of diazepam. Intervention: Monitor patients for increased sedation and reduce the dose of diazepam as needed.
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diazepam | Omeprazole | |
|---|---|---|
| Labeled for | Anxiety, Muscle spasms and spasticity | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0283 per tablet 10 mg tablet | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once