Methylprednisolone and Cyclosporine Interaction
Drug interaction information between Methylprednisolone and Cyclosporine.
Methylprednisolone and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methylprednisolone and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
When these two medications are used at the same time, they can each make the other more active in your system. This can lead to higher levels of both drugs in your body than intended.
FDA Label Information
Cyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently.
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Methylprednisolone + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Methylprednisolone's 29. In the minor band specifically: Methylprednisolone has 22 (also Acetaminophen, Warfarin, Nitrofurantoin, Valproate); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Methylprednisolone and Cyclosporine?
When these two medications are used at the same time, they can each make the other more active in your system. This can lead to higher levels of both drugs in your body than intended.
Cyclosporine carries more major-labeled pairs than Methylprednisolone
SPL source-record counts only. This page's band is minor · classes on file: Methylprednisolone (Corticosteroid); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Methylprednisolone's 1. This page itself is in the minor band, not the major band.
1 major · 6 moderate · 22 minor · 29 total
- Other minor peers for Methylprednisolone
- Acetaminophen
- Warfarin
- Nitrofurantoin
- Valproate
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.