What the FDA labels say about taking them together
Cyclosporine and methylprednisolone
Cyclosporine's FDA label of August 10, 2026 names methylprednisolone in its drug interactions section, and methylprednisolone's label names cyclosporine too. The methylprednisolone label: “Cyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the methylprednisolone FDA label on DailyMed (effective June 22, 2026, Mylan Pharmaceuticals Inc.).
What does the cyclosporine label say about methylprednisolone?
Cyclosporine label, drug interactionsdiltiazem; fluconazole; azithromycin; methylprednisolone; Allopurinol
Cyclosporine label, warningsNeurotoxicity There have been reports of convulsions in adult and pediatric patients receiving cyclosporine, particularly in combination with high dose methylprednisolone.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the methylprednisolone label say about cyclosporine?
Methylprednisolone label, drug interactionsMutual inhibition of metabolism occurs with concurrent use of cyclosporine and methylprednisolone; therefore, it is possible that adverse events associated with the individual use of either drug may be more apt to occur.
Solu-Medrol label (Pharmacia & Upjohn Company LLC, December 2, 2025), drug interactionsCyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently.
Source: FDA drug label (Solu-Medrol, NDA011856), Pharmacia & Upjohn Company LLC, effective December 2, 2025 (SPL set cd99be87-c8d9-48d6-a8e5-e081052e3f19), via openFDA
Source: FDA drug label (Methylprednisolone), NDA011153 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective June 22, 2026 (SPL set 22dd75d6-f89a-44f7-8ca6-b64c4e9806dd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Methylprednisolone | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Osteoarthritis, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Asthma, Eczema (atopic dermatitis), Anemia |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.121 per tablet 4 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once