Cyclosporine and Amlodipine Interaction
Drug interaction information between Cyclosporine and Amlodipine.
Cyclosporine and Amlodipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cyclosporine and Amlodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amlodipine can increase the amount of cyclosporine that stays in your body. This could lead to higher levels of the drug than your body needs.
FDA Label Information
Immunosuppressants Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when co-administered. Frequent monitoring of trough blood levels of cyclosporine and tacrolimus is recommended and adjust the dose when appropriate [see CLINICAL PHARMACOLOGY ( 12.3 )] .
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Frequently Asked Questions
What SPL severity band is on file for Cyclosporine + Amlodipine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Amlodipine's 15. In the minor band specifically: Cyclosporine has 60 (also Adalimumab, Amiodarone, Anidulafungin, Bempedoic Acid); Amlodipine has 10 (also Sildenafil, Amlodipine/Valsartan, Clarithromycin, Darunavir).
What mechanism field is on file for Cyclosporine and Amlodipine?
Amlodipine can increase the amount of cyclosporine that stays in your body. This could lead to higher levels of the drug than your body needs.
Cyclosporine carries more major-labeled pairs than Amlodipine
SPL source-record counts only. This page's band is minor · classes on file: Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)); Amlodipine (Calcium Channel Blocker).
Cyclosporine has 5 major-labeled pairs vs Amlodipine's 4. This page itself is in the minor band, not the major band.
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Anidulafungin
- Bempedoic Acid
4 major · 1 moderate · 10 minor · 15 total
- Other minor peers for Amlodipine
- Sildenafil
- Amlodipine/Valsartan
- Clarithromycin
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.