Cyclosporine and Adalimumab Interaction
Drug interaction information between Cyclosporine and Adalimumab.
Cyclosporine and Adalimumab have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cyclosporine and Adalimumab. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Adalimumab can change how your liver breaks down other medicines, which can cause the amount of cyclosporine in your blood to change.
FDA Label Information
Upon initiation or discontinuation of IDACIO in patients being treated with CYP450 substrates with a narrow therapeutic index, monitoring of the effect (e.g., warfarin) or drug concentration (e.g., cyclosporine or theophylline) is recommended and the individual dose of the drug product may be adjusted as needed.
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Adalimumab Also Interacts With
- Abatacept moderate
- Warfarin minor
- Methotrexate minor
- Theophylline minor
Frequently Asked Questions
What SPL severity band is on file for Cyclosporine + Adalimumab?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Adalimumab's 5. In the minor band specifically: Cyclosporine has 60 (also Amiodarone, Amlodipine, Anidulafungin, Bempedoic Acid); Adalimumab has 4 (also Warfarin, Methotrexate, Theophylline).
What mechanism field is on file for Cyclosporine and Adalimumab?
Adalimumab can change how your liver breaks down other medicines, which can cause the amount of cyclosporine in your blood to change.
Cyclosporine carries more major-labeled pairs than Adalimumab
SPL source-record counts only. This page's band is minor · classes on file: Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)); Adalimumab (TNF-Alpha Inhibitor (Biologic)).
Cyclosporine has 5 major-labeled pairs vs Adalimumab's 0. This page itself is in the minor band, not the major band.
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Amiodarone
- Amlodipine
- Anidulafungin
- Bempedoic Acid
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Adalimumab
- Warfarin
- Methotrexate
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.