Cyclosporine and Amiodarone Interaction
Drug interaction information between Cyclosporine and Amiodarone.
Cyclosporine and Amiodarone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cyclosporine and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiodarone can cause the levels of cyclosporine in your blood to rise. This can lead to kidney problems, even if the dose of cyclosporine is lowered.
FDA Label Information
Cyclosporine Increased plasma levels of cyclosporine have been reported resulting in elevated creatinine, despite reduction of cyclosporine dose. Monitor cyclosporine drug levels and renal function with concomitant use.
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Cyclosporine + Amiodarone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Amiodarone's 42. In the minor band specifically: Cyclosporine has 60 (also Adalimumab, Amlodipine, Anidulafungin, Bempedoic Acid); Amiodarone has 29 (also Atorvastatin, Clonidine, Diltiazem, Verapamil).
What mechanism field is on file for Cyclosporine and Amiodarone?
Amiodarone can cause the levels of cyclosporine in your blood to rise. This can lead to kidney problems, even if the dose of cyclosporine is lowered.
Cyclosporine carries more major-labeled pairs than Amiodarone
SPL source-record counts only. This page's band is minor · classes on file: Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)); Amiodarone (Class III Antiarrhythmic).
Cyclosporine has 5 major-labeled pairs vs Amiodarone's 4. This page itself is in the minor band, not the major band.
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amlodipine
- Anidulafungin
- Bempedoic Acid
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Atorvastatin
- Clonidine
- Diltiazem
- Verapamil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.