Amlodipine and Simvastatin Interaction
Drug interaction information between Amlodipine and Simvastatin.
Amlodipine and Simvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Amlodipine and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amlodipine makes it harder for your body to clear simvastatin, which raises the level of the cholesterol medicine in your blood.
FDA Label Information
7 DRUG INTERACTIONS Do not exceed doses greater than 20 mg daily of simvastatin. 7.2 Impact of Amlodipine on Other Drugs Simvastatin Co-administration of simvastatin with amlodipine increases the systemic exposure of simvastatin. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily [see CLINICAL PHARMACOLOGY ( 12.3 )] .
Amlodipine Also Interacts With
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
- Sildenafil minor
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Amlodipine + Simvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Amlodipine's 15. In the major band specifically: Amlodipine has 4 (also Amlodipine/Benazepril, Ezetimibe, Ezetimibe/Simvastatin); Simvastatin has 11 (also Diltiazem, Verapamil, Cyclosporine, Amiodarone).
What mechanism field is on file for Amlodipine and Simvastatin?
Amlodipine makes it harder for your body to clear simvastatin, which raises the level of the cholesterol medicine in your blood.
Simvastatin carries more major-labeled pairs than Amlodipine
SPL source-record counts only. This page's band is major · classes on file: Amlodipine (Calcium Channel Blocker); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Amlodipine's 4.
4 major · 1 moderate · 10 minor · 15 total
- Other major peers for Amlodipine
- Amlodipine/Benazepril
- Ezetimibe
- Ezetimibe/Simvastatin
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Verapamil
- Cyclosporine
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.