What the FDA labels say about taking them together
Amlodipine and simvastatin
Amlodipine's FDA label of February 15, 2023 names simvastatin in its drug interactions section, and simvastatin's label names amlodipine too. The simvastatin label: “For patients taking amiodarone, amlodipine, or ranolazine, do not exceed ZOCOR 20 mg daily.”
Check it at the source: the amlodipine FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the amlodipine label say about simvastatin?
Amlodipine label, drug interactionsAmlodipine on Other Drugs Simvastatin Co-administration of simvastatin with amlodipine increases the systemic exposure of simvastatin.
Source: FDA drug label (Norvasc), Viatris Specialty LLC, effective February 15, 2023 (SPL set 7367289c-b0b0-466a-83e2-558e2985c29f), via openFDA; the full label on DailyMed
What does the simvastatin label say about amlodipine?
Simvastatin label, drug interactionsFor patients taking amiodarone, amlodipine, or ranolazine, do not exceed ZOCOR 20 mg daily [see Dosage and Administration (2.5) ].
Simvastatin label, warnings and precautionsZOCOR dosage modifications are recommended for patients taking lomitapide, verapamil, diltiazem, dronedarone, amiodarone, amlodipine or ranolazine [see Dosage and Administration (2.5) ].
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Which combination products and biosimilars carry the same label text?
Their labels quote the same sentences for their ingredient; each has its own page with its own label dates.
Both medicines on the record
| Amlodipine | Simvastatin | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart attack and coronary artery disease | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0102 per tablet 5 mg tablet | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once