What the FDA labels say about taking them together
Amlodipine and sildenafil
Amlodipine's FDA label of February 15, 2023 names sildenafil in its drug interactions section, and sildenafil's label names amlodipine too. The amlodipine label: “Sildenafil Monitor for hypotension when sildenafil is co-administered with amlodipine.”
Check it at the source: the amlodipine FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC); the sildenafil FDA label on DailyMed (effective November 17, 2023, Viatris Specialty LLC).
What does the amlodipine label say about sildenafil?
Amlodipine label, drug interactionsSildenafil Monitor for hypotension when sildenafil is co-administered with amlodipine [see Clinical Pharmacology (12.2) ].
Source: FDA drug label (Norvasc), Viatris Specialty LLC, effective February 15, 2023 (SPL set 7367289c-b0b0-466a-83e2-558e2985c29f), via openFDA; the full label on DailyMed
What does the sildenafil label say about amlodipine?
Sildenafil label, drug interactionsAmlodipine When VIAGRA 100 mg was co-administered with amlodipine (5 mg or 10 mg) to hypertensive patients, the mean additional reduction on supine blood pressure was 8 mmHg systolic and 7 mmHg diastolic [ see Warnings and Precautions (5.5), Clinical Pharmacology (12.2) ].
Sildenafil label, warnings and precautionsIn a separate drug interaction study, when amlodipine, 5 mg or 10 mg, and VIAGRA, 100 mg were orally administered concomitantly to hypertensive patients mean additional blood pressure reduction of 8 mmHg systolic and 7 mmHg diastolic were noted [ see Drug Interactions (7.3) and Clinical Pharmacology (12.2) ].
Source: FDA drug label (Vybrique, NDA210858), IBSA Pharma Inc., effective July 8, 2026 (SPL set 9213fec1-e0c0-4ef7-9718-d97922a3f4d8), via openFDA
Source: FDA drug label (Viagra), Viatris Specialty LLC, effective November 17, 2023 (SPL set d905dc8d-917f-4ea3-a4ee-a1ecf6967d4e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amlodipine | Sildenafil | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart attack and coronary artery disease | Erectile dysfunction, Pulmonary arterial hypertension |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0102 per tablet 5 mg tablet | $0.132 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once