Amlodipine and Sildenafil Interaction
Drug interaction information between Amlodipine and Sildenafil.
Amlodipine and Sildenafil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amlodipine and Sildenafil. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs can lower your blood pressure, and taking them together might cause your blood pressure to drop too low.
What To Do
You should monitor your blood pressure closely and watch for signs of dizziness or lightheadedness.
FDA Label Information
Sildenafil Monitor for hypotension when sildenafil is co-administered with amlodipine [see CLINICAL PHARMACOLOGY ( 12.2 )] .
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Sildenafil Also Interacts With
- Ketoconazole major
- Erythromycin major
- Itraconazole major
- Darunavir major
- Hydralazine/Isosorbide Dinitrate major
Frequently Asked Questions
Can I take Amlodipine and Sildenafil together?
This is a minor interaction. You should monitor your blood pressure closely and watch for signs of dizziness or lightheadedness.
How serious is the interaction between Amlodipine and Sildenafil?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Amlodipine and Sildenafil interact?
Both drugs can lower your blood pressure, and taking them together might cause your blood pressure to drop too low.
Understanding the Amlodipine and Sildenafil Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Amlodipine belongs to the Calcium Channel Blocker class and Sildenafil belongs to the PDE5 Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs can lower your blood pressure, and taking them together might cause your blood pressure to drop too low. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Amlodipine has 15 total documented interactions on file in this dataset, and Sildenafil has 10. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You should monitor your blood pressure closely and watch for signs of dizziness or lightheadedness. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Amlodipine or Sildenafil based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.