Amlodipine and Sildenafil Interaction
Drug interaction information between Amlodipine and Sildenafil.
Amlodipine and Sildenafil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amlodipine and Sildenafil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can lower your blood pressure, and taking them together might cause your blood pressure to drop too low.
FDA Label Information
Sildenafil Monitor for hypotension when sildenafil is co-administered with amlodipine [see CLINICAL PHARMACOLOGY ( 12.2 )] .
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Sildenafil Also Interacts With
- Ketoconazole major
- Erythromycin major
- Itraconazole major
- Darunavir major
- Hydralazine/Isosorbide Dinitrate major
Frequently Asked Questions
What SPL severity band is on file for Amlodipine + Sildenafil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amlodipine has 15 labeled pairs on file vs Sildenafil's 10. In the minor band specifically: Amlodipine has 10 (also Cyclosporine, Amlodipine/Valsartan, Clarithromycin, Darunavir); Sildenafil has 3 (also Amlodipine/Valsartan, Nitroglycerin).
What mechanism field is on file for Amlodipine and Sildenafil?
Both drugs can lower your blood pressure, and taking them together might cause your blood pressure to drop too low.
Sildenafil carries more major-labeled pairs than Amlodipine
SPL source-record counts only. This page's band is minor · classes on file: Amlodipine (Calcium Channel Blocker); Sildenafil (PDE5 Inhibitor).
Sildenafil has 6 major-labeled pairs vs Amlodipine's 4. This page itself is in the minor band, not the major band.
4 major · 1 moderate · 10 minor · 15 total
- Other minor peers for Amlodipine
- Cyclosporine
- Amlodipine/Valsartan
- Clarithromycin
- Darunavir
6 major · 1 moderate · 3 minor · 10 total
- Other minor peers for Sildenafil
- Amlodipine/Valsartan
- Nitroglycerin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.