Amlodipine and Amlodipine/Benazepril Interaction
Drug interaction information between Amlodipine and Amlodipine/Benazepril.
Amlodipine and Amlodipine/Benazepril have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Amlodipine and Amlodipine/Benazepril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination pill already contains amlodipine, so taking extra amlodipine separately can lead to an overdose and dangerously low blood pressure.
FDA Label Information
7 DRUG INTERACTIONS • Potassium supplements/potassium-sparing diuretics: hyperkalemia ( 7.1 ) • Lithium: Increased serum lithium levels; toxicity symptoms ( 7.1 ) • Injectable gold: facial flushing, nausea, vomiting, hypotension ( 7.1 ) • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Risk of renal dysfunction, loss of antihypertensive effect ( 7.1 ) • Do not exceed doses greater than 20 mg daily of simvastatin ( 7.1 ) • mTOR inhibitors: increased risk of angioedema ( 7.1 ) • Dual inhibition of the RAS: Increased risk of renal impairment, hypotension, and hyperkalemia ( 7.1 ) • Neprilysin...
Amlodipine Also Interacts With
- Simvastatin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
- Sildenafil minor
Amlodipine/Benazepril Also Interacts With
- Simvastatin major
- Lithium major
- Aliskiren major
- Spironolactone moderate
- Amiloride moderate
Frequently Asked Questions
What SPL severity band is on file for Amlodipine + Amlodipine/Benazepril?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amlodipine has 15 labeled pairs on file vs Amlodipine/Benazepril's 7. In the major band specifically: Amlodipine has 4 (also Simvastatin, Ezetimibe, Ezetimibe/Simvastatin); Amlodipine/Benazepril has 4 (also Simvastatin, Lithium, Aliskiren).
What mechanism field is on file for Amlodipine and Amlodipine/Benazepril?
This combination pill already contains amlodipine, so taking extra amlodipine separately can lead to an overdose and dangerously low blood pressure.
Amlodipine's labeled portfolio outnumbers Amlodipine/Benazepril
SPL source-record counts only. This page's band is major · classes on file: Amlodipine (Calcium Channel Blocker); Amlodipine/Benazepril (Calcium Channel Blocker / ACE Inhibitor Combination).
4 major · 1 moderate · 10 minor · 15 total
- Other major peers for Amlodipine
- Simvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
4 major · 2 moderate · 1 minor · 7 total
- Other major peers for Amlodipine/Benazepril
- Simvastatin
- Lithium
- Aliskiren
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.