Amlodipine and Ezetimibe Interaction
Drug interaction information between Amlodipine and Ezetimibe.
Amlodipine and Ezetimibe have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Amlodipine and Ezetimibe. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amlodipine can increase the levels of the cholesterol medicine in your blood, which may lead to side effects.
FDA Label Information
For patients taking amiodarone, amlodipine, or ranolazine, do not exceed ezetimibe and simvastatin 10 mg/20 mg daily [see Dosage and Administration ( 2.3 )].
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
- Sildenafil minor
Ezetimibe Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Amlodipine + Ezetimibe?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe has 25 labeled pairs on file vs Amlodipine's 15. In the major band specifically: Amlodipine has 4 (also Simvastatin, Amlodipine/Benazepril, Ezetimibe/Simvastatin); Ezetimibe has 8 (also Diltiazem, Verapamil, Cyclosporine, Amiodarone).
What mechanism field is on file for Amlodipine and Ezetimibe?
Amlodipine can increase the levels of the cholesterol medicine in your blood, which may lead to side effects.
Ezetimibe carries more major-labeled pairs than Amlodipine
SPL source-record counts only. This page's band is major · classes on file: Amlodipine (Calcium Channel Blocker); Ezetimibe (Cholesterol Absorption Inhibitor).
Ezetimibe has 8 major-labeled pairs vs Amlodipine's 4.
4 major · 1 moderate · 10 minor · 15 total
- Other major peers for Amlodipine
- Simvastatin
- Amlodipine/Benazepril
- Ezetimibe/Simvastatin
8 major · 4 moderate · 13 minor · 25 total
- Other major peers for Ezetimibe
- Diltiazem
- Verapamil
- Cyclosporine
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.