What the FDA labels say about taking them together
Amlodipine and cyclosporine
Amlodipine's FDA label of February 15, 2023 names cyclosporine in its drug interactions section; cyclosporine's label does not name amlodipine itself but warns about its class (Calcium channel blockers, Calcium channel blockers (dihydropyridines)). The amlodipine label: “Immunosuppressants Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when co-administered.”
Check it at the source: the amlodipine FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the amlodipine label say about cyclosporine?
Amlodipine label, drug interactionsImmunosuppressants Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when co-administered.
Source: FDA drug label (Norvasc), Viatris Specialty LLC, effective February 15, 2023 (SPL set 7367289c-b0b0-466a-83e2-558e2985c29f), via openFDA; the full label on DailyMed
What does the cyclosporine label say about amlodipine?
Cyclosporine's label does not name amlodipine itself; it warns about its class (Calcium channel blockers, Calcium channel blockers (dihydropyridines)):
Cyclosporine label, drug interactionsDrugs That Increase Cyclosporine Concentrations Calcium Channel Blockers Antifungals Antibiotics Glucocorticoids Other Drugs diltiazem fluconazole azithromycin methylprednisolone Allopurinol nicardipine itraconazole clarithromycin Amiodarone verapamil ketoconazole erythromycin Bromocriptine voriconazole quinupristin/ dalfopristin colchicine danazol imatinib metoclopramide nefazodone oral contraceptives HIV Protease Inhibitors The HIV protease inhibitors (e.g., indinavir, nelfinavir, ritonavir, and saquinavir) are …
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amlodipine | Cyclosporine | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart attack and coronary artery disease | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0102 per tablet 5 mg tablet | $1.04 per unit 0.05% eye emulsion |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once