Amlodipine and Amlodipine/Valsartan Interaction
Drug interaction information between Amlodipine and Amlodipine/Valsartan.
Amlodipine and Amlodipine/Valsartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amlodipine and Amlodipine/Valsartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs contain amlodipine, so taking them together results in a double dose. This can cause your blood pressure to drop too low and may cause swelling in your ankles.
FDA Label Information
Amlodipine Impact of Other Drugs on Amlodipine CYP3A Inhibitors Coadministration with CYP3A inhibitors (moderate and strong) results in increased systemic exposure to amlodipine and may require dose reduction. Monitor for symptoms of hypotension and edema when amlodipine is coadministered with CYP3A inhibitors to determine the need for dose adjustment [see Clinical Pharmacology (12.3)] . CYP3A Inducers No information is available on the quantitative effects of CYP3A inducers on amlodipine.
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Cyclosporine moderate
- Lithium moderate
- Hydrochlorothiazide minor
Frequently Asked Questions
What SPL severity band is on file for Amlodipine + Amlodipine/Valsartan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amlodipine has 15 labeled pairs on file vs Amlodipine/Valsartan's 14. In the minor band specifically: Amlodipine has 10 (also Sildenafil, Cyclosporine, Clarithromycin, Darunavir); Amlodipine/Valsartan has 10 (also Hydrochlorothiazide, Spironolactone, Valsartan, Sildenafil).
What mechanism field is on file for Amlodipine and Amlodipine/Valsartan?
Both of these drugs contain amlodipine, so taking them together results in a double dose. This can cause your blood pressure to drop too low and may cause swelling in your ankles.
Amlodipine carries more major-labeled pairs than Amlodipine/Valsartan
SPL source-record counts only. This page's band is minor · classes on file: Amlodipine (Calcium Channel Blocker); Amlodipine/Valsartan (CCB / ARB Combination).
Amlodipine has 4 major-labeled pairs vs Amlodipine/Valsartan's 2. This page itself is in the minor band, not the major band.
4 major · 1 moderate · 10 minor · 15 total
- Other minor peers for Amlodipine
- Sildenafil
- Cyclosporine
- Clarithromycin
- Darunavir
2 major · 2 moderate · 10 minor · 14 total
- Other minor peers for Amlodipine/Valsartan
- Hydrochlorothiazide
- Spironolactone
- Valsartan
- Sildenafil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.