Amlodipine and Clarithromycin Interaction
Drug interaction information between Amlodipine and Clarithromycin.
Amlodipine and Clarithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amlodipine and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin blocks the liver enzymes that normally break down amlodipine. This can cause amlodipine to build up in your body and lower your blood pressure too much.
FDA Label Information
Amlodipine Diltiazem Amlodipine, Diltiazem: [See Warnings and Precautions ( 5.4 )] Nifedipine Nifedipine: Nifedipine is a substrate for CYP3A.
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Amlodipine + Clarithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Amlodipine's 15. In the minor band specifically: Amlodipine has 10 (also Sildenafil, Cyclosporine, Amlodipine/Valsartan, Darunavir); Clarithromycin has 30 (also Lorazepam, Diltiazem, Erythromycin, Temazepam).
What mechanism field is on file for Amlodipine and Clarithromycin?
Clarithromycin blocks the liver enzymes that normally break down amlodipine. This can cause amlodipine to build up in your body and lower your blood pressure too much.
Clarithromycin carries more major-labeled pairs than Amlodipine
SPL source-record counts only. This page's band is minor · classes on file: Amlodipine (Calcium Channel Blocker); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Amlodipine's 4. This page itself is in the minor band, not the major band.
4 major · 1 moderate · 10 minor · 15 total
- Other minor peers for Amlodipine
- Sildenafil
- Cyclosporine
- Amlodipine/Valsartan
- Darunavir
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Lorazepam
- Diltiazem
- Erythromycin
- Temazepam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.