Etonogestrel and Atorvastatin Interaction
Drug interaction information between Etonogestrel and Atorvastatin.
Etonogestrel and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etonogestrel and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Atorvastatin can cause the levels of the hormones in your birth control to increase in your bloodstream.
FDA Label Information
Substances increasing the plasma concentrations of CHCs Co-administration of atorvastatin and certain CHCs containing ethinyl estradiol increase AUC values for ethinyl estradiol by approximately 20-25%.
Etonogestrel Also Interacts With
- Estradiol moderate
- Glecaprevir/Pibrentasvir moderate
- Amoxicillin minor
- Lamotrigine minor
- Topiramate minor
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Etonogestrel + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Etonogestrel's 29. In the minor band specifically: Etonogestrel has 27 (also Amoxicillin, Lamotrigine, Topiramate, Doxycycline); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Etonogestrel and Atorvastatin?
Atorvastatin can cause the levels of the hormones in your birth control to increase in your bloodstream.
Atorvastatin carries more major-labeled pairs than Etonogestrel
SPL source-record counts only. This page's band is minor · classes on file: Etonogestrel (Progestin (Implant)); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Etonogestrel's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 27 minor · 29 total
- Other minor peers for Etonogestrel
- Amoxicillin
- Lamotrigine
- Topiramate
- Doxycycline
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.