Etonogestrel and Amoxicillin Interaction
Drug interaction information between Etonogestrel and Amoxicillin.
Etonogestrel and Amoxicillin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etonogestrel and Amoxicillin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
This antibiotic does not change the levels of birth control hormones in your blood.
What To Do
You can take these two medications together without needing to adjust your doses or use extra protection.
FDA Label Information
The serum concentrations of etonogestrel and ethinyl estradiol were not affected by concomitant administration of oral amoxicillin or doxycycline in standard dosages during 10 days of antibiotic treatment.
Etonogestrel Also Interacts With
- Estradiol moderate
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Lamotrigine minor
- Topiramate minor
Amoxicillin Also Interacts With
- Lansoprazole major
- Rabeprazole major
- Theophylline major
- Allopurinol moderate
- Probenecid moderate
Frequently Asked Questions
Can I take Etonogestrel and Amoxicillin together?
This is a minor interaction. You can take these two medications together without needing to adjust your doses or use extra protection.
How serious is the interaction between Etonogestrel and Amoxicillin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Etonogestrel and Amoxicillin interact?
This antibiotic does not change the levels of birth control hormones in your blood.
Understanding the Etonogestrel and Amoxicillin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Etonogestrel belongs to the Progestin (Implant) class and Amoxicillin belongs to the Penicillin Antibiotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: This antibiotic does not change the levels of birth control hormones in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Etonogestrel has 29 total documented interactions on file in this dataset, and Amoxicillin has 12. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can take these two medications together without needing to adjust your doses or use extra protection. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Etonogestrel or Amoxicillin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.