Etonogestrel and Amoxicillin Interaction
Drug interaction information between Etonogestrel and Amoxicillin.
Etonogestrel and Amoxicillin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etonogestrel and Amoxicillin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antibiotic does not change the levels of birth control hormones in your blood.
FDA Label Information
The serum concentrations of etonogestrel and ethinyl estradiol were not affected by concomitant administration of oral amoxicillin or doxycycline in standard dosages during 10 days of antibiotic treatment.
Etonogestrel Also Interacts With
- Estradiol moderate
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Lamotrigine minor
- Topiramate minor
Amoxicillin Also Interacts With
- Lansoprazole major
- Rabeprazole major
- Theophylline major
- Allopurinol moderate
- Probenecid moderate
Frequently Asked Questions
What SPL severity band is on file for Etonogestrel + Amoxicillin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Etonogestrel has 29 labeled pairs on file vs Amoxicillin's 12. In the minor band specifically: Etonogestrel has 27 (also Atorvastatin, Lamotrigine, Topiramate, Doxycycline); Amoxicillin has 7 (also Estradiol, Progesterone, Amoxicillin/Clavulanate, Ethinyl Estradiol).
What mechanism field is on file for Etonogestrel and Amoxicillin?
This antibiotic does not change the levels of birth control hormones in your blood.
Amoxicillin carries more major-labeled pairs than Etonogestrel
SPL source-record counts only. This page's band is minor · classes on file: Etonogestrel (Progestin (Implant)); Amoxicillin (Penicillin Antibiotic).
Amoxicillin has 3 major-labeled pairs vs Etonogestrel's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 27 minor · 29 total
- Other minor peers for Etonogestrel
- Atorvastatin
- Lamotrigine
- Topiramate
- Doxycycline
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Amoxicillin
- Estradiol
- Progesterone
- Amoxicillin/Clavulanate
- Ethinyl Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.