Etonogestrel and Glecaprevir/Pibrentasvir Interaction
Drug interaction information between Etonogestrel and Glecaprevir/Pibrentasvir.
Etonogestrel and Glecaprevir/Pibrentasvir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Etonogestrel and Glecaprevir/Pibrentasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medicines together can cause your liver enzymes to rise, which is a sign of liver stress. This happens because both drugs affect how the liver functions at the same time.
FDA Label Information
Concomitant use with some other HCV antiviral medicinal products, such as those containing glecaprevir/pibrentasvir, may increase the risk of ALT elevations [see Warnings and Precautions (5.4)].
Etonogestrel Also Interacts With
- Estradiol moderate
- Atorvastatin minor
- Amoxicillin minor
- Lamotrigine minor
- Topiramate minor
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Frequently Asked Questions
What SPL severity band is on file for Etonogestrel + Glecaprevir/Pibrentasvir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Etonogestrel's 29. In the moderate band specifically: Etonogestrel has 2 (also Estradiol); Glecaprevir/Pibrentasvir has 9 (also Cyclosporine, Darunavir, Estradiol, Ethinyl Estradiol).
What mechanism field is on file for Etonogestrel and Glecaprevir/Pibrentasvir?
Taking these medicines together can cause your liver enzymes to rise, which is a sign of liver stress. This happens because both drugs affect how the liver functions at the same time.
Glecaprevir/Pibrentasvir carries more major-labeled pairs than Etonogestrel
SPL source-record counts only. This page's band is moderate · classes on file: Etonogestrel (Progestin (Implant)); Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)).
Glecaprevir/Pibrentasvir has 3 major-labeled pairs vs Etonogestrel's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 27 minor · 29 total
- Other moderate peers for Etonogestrel
- Estradiol
3 major · 9 moderate · 26 minor · 38 total
- Other moderate peers for Glecaprevir/Pibrentasvir
- Cyclosporine
- Darunavir
- Estradiol
- Ethinyl Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.