Etonogestrel and Lamotrigine Interaction
Drug interaction information between Etonogestrel and Lamotrigine.
Etonogestrel and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etonogestrel and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The birth control causes your body to clear the seizure medicine more quickly, which lowers its levels in your blood.
FDA Label Information
A significant decrease in the plasma concentrations of lamotrigine has been shown, likely due to induction of lamotrigine glucuronidation. This may reduce seizure control; therefore, dosage adjustments of lamotrigine may be necessary.
Etonogestrel Also Interacts With
- Estradiol moderate
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Amoxicillin minor
- Topiramate minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Etonogestrel + Lamotrigine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Etonogestrel has 29 labeled pairs on file vs Lamotrigine's 24. In the minor band specifically: Etonogestrel has 27 (also Atorvastatin, Amoxicillin, Topiramate, Doxycycline); Lamotrigine has 22 (also Valproate, Carbamazepine, Rifampin, Phenytoin).
What mechanism field is on file for Etonogestrel and Lamotrigine?
The birth control causes your body to clear the seizure medicine more quickly, which lowers its levels in your blood.
Etonogestrel's labeled portfolio outnumbers Lamotrigine
SPL source-record counts only. This page's band is minor · classes on file: Etonogestrel (Progestin (Implant)); Lamotrigine (Anticonvulsant).
0 major · 2 moderate · 27 minor · 29 total
- Other minor peers for Etonogestrel
- Atorvastatin
- Amoxicillin
- Topiramate
- Doxycycline
0 major · 2 moderate · 22 minor · 24 total
- Other minor peers for Lamotrigine
- Valproate
- Carbamazepine
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.