What the FDA labels say about taking them together
Etonogestrel and lamotrigine
Etonogestrel's FDA label of May 28, 2026 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name etonogestrel. The etonogestrel label: “Consequently, plasma concentrations may either increase or decrease (for example, lamotrigine).”
Check it at the source: the etonogestrel FDA label on DailyMed (effective May 28, 2026, Organon LLC); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the etonogestrel label say about lamotrigine?
Etonogestrel label, drug interactionsConsequently, plasma concentrations may either increase (for example, cyclosporine) or decrease (for example, lamotrigine).
Source: FDA drug label (Nexplanon), Organon LLC, effective May 28, 2026 (SPL set 487f8a62-e142-457c-97cc-2e398fde7594), via openFDA; the full label on DailyMed
What does the lamotrigine label say about etonogestrel?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etonogestrel | Lamotrigine | |
|---|---|---|
| Labeled for | Birth control | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once