Etonogestrel and Doxycycline Interaction
Drug interaction information between Etonogestrel and Doxycycline.
Etonogestrel and Doxycycline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etonogestrel and Doxycycline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Doxycycline does not change the levels of etonogestrel in the body.
FDA Label Information
The serum concentrations of etonogestrel and ethinyl estradiol were not affected by concomitant administration of oral amoxicillin or doxycycline in standard dosages during 10 days of antibiotic treatment.
Etonogestrel Also Interacts With
- Estradiol moderate
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Amoxicillin minor
- Lamotrigine minor
Doxycycline Also Interacts With
- Tetracycline moderate
- Rifampin moderate
- Carbamazepine minor
- Bismuth Subsalicylate minor
- Phenytoin minor
Frequently Asked Questions
What SPL severity band is on file for Etonogestrel + Doxycycline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Etonogestrel has 29 labeled pairs on file vs Doxycycline's 9. In the minor band specifically: Etonogestrel has 27 (also Atorvastatin, Amoxicillin, Lamotrigine, Topiramate); Doxycycline has 7 (also Carbamazepine, Bismuth Subsalicylate, Phenytoin, Doxycycline Hyclate).
What mechanism field is on file for Etonogestrel and Doxycycline?
Doxycycline does not change the levels of etonogestrel in the body.
Etonogestrel's labeled portfolio outnumbers Doxycycline
SPL source-record counts only. This page's band is minor · classes on file: Etonogestrel (Progestin (Implant)); Doxycycline (Tetracycline Antibiotic).
0 major · 2 moderate · 27 minor · 29 total
- Other minor peers for Etonogestrel
- Atorvastatin
- Amoxicillin
- Lamotrigine
- Topiramate
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Doxycycline
- Carbamazepine
- Bismuth Subsalicylate
- Phenytoin
- Doxycycline Hyclate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.