Etonogestrel and Topiramate Interaction
Drug interaction information between Etonogestrel and Topiramate.
Etonogestrel and Topiramate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etonogestrel and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine can speed up how your body breaks down birth control, making it less likely to prevent pregnancy.
FDA Label Information
Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include: phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St.
Etonogestrel Also Interacts With
- Estradiol moderate
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Amoxicillin minor
- Lamotrigine minor
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Etonogestrel + Topiramate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Topiramate has 30 labeled pairs on file vs Etonogestrel's 29. In the minor band specifically: Etonogestrel has 27 (also Atorvastatin, Amoxicillin, Lamotrigine, Doxycycline); Topiramate has 27 (also Hydrochlorothiazide, Amitriptyline, Pioglitazone, Carbamazepine).
What mechanism field is on file for Etonogestrel and Topiramate?
This medicine can speed up how your body breaks down birth control, making it less likely to prevent pregnancy.
Topiramate's labeled portfolio outnumbers Etonogestrel
SPL source-record counts only. This page's band is minor · classes on file: Etonogestrel (Progestin (Implant)); Topiramate (Anticonvulsant).
0 major · 2 moderate · 27 minor · 29 total
- Other minor peers for Etonogestrel
- Atorvastatin
- Amoxicillin
- Lamotrigine
- Doxycycline
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Hydrochlorothiazide
- Amitriptyline
- Pioglitazone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.