Ethacrynic Acid and Furosemide Interaction
Drug interaction information between Ethacrynic Acid and Furosemide.
Ethacrynic Acid and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethacrynic Acid and Furosemide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two medicines together can increase the risk of hearing loss or ear damage.
FDA Label Information
Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity.
Ethacrynic Acid Also Interacts With
- Lithium moderate
- Warfarin minor
- Fludrocortisone minor
- Torsemide minor
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Ethacrynic Acid + Furosemide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Ethacrynic Acid's 5. In the minor band specifically: Ethacrynic Acid has 4 (also Warfarin, Fludrocortisone, Torsemide); Furosemide has 29 (also Methotrexate, Norepinephrine, Indomethacin, Sucralfate).
What mechanism field is on file for Ethacrynic Acid and Furosemide?
Using these two medicines together can increase the risk of hearing loss or ear damage.
Furosemide carries more major-labeled pairs than Ethacrynic Acid
SPL source-record counts only. This page's band is minor · classes on file: Ethacrynic Acid (Loop Diuretic); Furosemide (Loop Diuretic).
Furosemide has 3 major-labeled pairs vs Ethacrynic Acid's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Ethacrynic Acid
- Warfarin
- Fludrocortisone
- Torsemide
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Indomethacin
- Sucralfate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.