What the FDA labels say about taking them together
Ethacrynic acid and lithium
Ethacrynic acid's FDA label of August 31, 2020 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name ethacrynic acid. The ethacrynic acid label: “Drug Interactions Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.”
Check it at the source: the ethacrynic acid FDA label on DailyMed (effective August 31, 2020, Bausch Health US, LLC); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the ethacrynic acid label say about lithium?
Ethacrynic acid label, drug interactionsDrug Interactions Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.
Ethacrynic acid label, warningsLithium generally should not be given with diuretics (see PRECAUTIONS, Drug Interactions ).
Source: FDA drug label (EDECRIN), Bausch Health US, LLC, effective August 31, 2020 (SPL set 1efe378e-fee1-4ae9-8ea5-0fe2265fe2d8), via openFDA; the full label on DailyMed
What does the lithium label say about ethacrynic acid?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name ethacrynic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethacrynic acid | Lithium | |
|---|---|---|
| Labeled for | Edema (fluid retention), Heart failure | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.807 per tablet 25 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once