Ethacrynic Acid and Lithium Interaction
Drug interaction information between Ethacrynic Acid and Lithium.
Ethacrynic Acid and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ethacrynic Acid and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ethacrynic acid makes it harder for the kidneys to remove lithium from the body. This can cause lithium to build up to dangerous levels.
FDA Label Information
Drug Interactions Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy.
Ethacrynic Acid Also Interacts With
- Warfarin minor
- Fludrocortisone minor
- Furosemide minor
- Torsemide minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Ethacrynic Acid + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Ethacrynic Acid's 5. In the moderate band specifically: Ethacrynic Acid has 1; Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Ethacrynic Acid and Lithium?
Ethacrynic acid makes it harder for the kidneys to remove lithium from the body. This can cause lithium to build up to dangerous levels.
Lithium carries more major-labeled pairs than Ethacrynic Acid
SPL source-record counts only. This page's band is moderate · classes on file: Ethacrynic Acid (Loop Diuretic); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Ethacrynic Acid's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 4 minor · 5 total
Ethacrynic Acid has no other moderate-band peer in this dataset besides Lithium.
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.