Ethacrynic Acid and Warfarin Interaction
Drug interaction information between Ethacrynic Acid and Warfarin.
Ethacrynic Acid and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethacrynic Acid and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ethacrynic acid knocks warfarin off the proteins it usually sticks to in your blood. This leaves more active warfarin in your system, which can increase the risk of bleeding.
FDA Label Information
A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs.
Ethacrynic Acid Also Interacts With
- Lithium moderate
- Fludrocortisone minor
- Furosemide minor
- Torsemide minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Ethacrynic Acid + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Ethacrynic Acid's 5. In the minor band specifically: Ethacrynic Acid has 4 (also Fludrocortisone, Furosemide, Torsemide); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Ethacrynic Acid and Warfarin?
Ethacrynic acid knocks warfarin off the proteins it usually sticks to in your blood. This leaves more active warfarin in your system, which can increase the risk of bleeding.
Warfarin carries more major-labeled pairs than Ethacrynic Acid
SPL source-record counts only. This page's band is minor · classes on file: Ethacrynic Acid (Loop Diuretic); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Ethacrynic Acid's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Ethacrynic Acid
- Fludrocortisone
- Furosemide
- Torsemide
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.