Ethacrynic Acid and Fludrocortisone Interaction
Drug interaction information between Ethacrynic Acid and Fludrocortisone.
Ethacrynic Acid and Fludrocortisone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethacrynic Acid and Fludrocortisone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs cause the body to get rid of potassium through the urine. This can lead to very low potassium levels in your blood.
FDA Label Information
Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide) – enhanced hypokalemia.
Ethacrynic Acid Also Interacts With
- Lithium moderate
- Warfarin minor
- Furosemide minor
- Torsemide minor
Fludrocortisone Also Interacts With
- Furosemide minor
- Aspirin minor
- Rifampin minor
- Amphotericin B minor
- Phenytoin minor
Frequently Asked Questions
What SPL severity band is on file for Ethacrynic Acid + Fludrocortisone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fludrocortisone has 6 labeled pairs on file vs Ethacrynic Acid's 5. In the minor band specifically: Ethacrynic Acid has 4 (also Warfarin, Furosemide, Torsemide); Fludrocortisone has 6 (also Furosemide, Aspirin, Rifampin, Amphotericin B).
What mechanism field is on file for Ethacrynic Acid and Fludrocortisone?
Both drugs cause the body to get rid of potassium through the urine. This can lead to very low potassium levels in your blood.
Fludrocortisone's labeled portfolio outnumbers Ethacrynic Acid
SPL source-record counts only. This page's band is minor · classes on file: Ethacrynic Acid (Loop Diuretic); Fludrocortisone (Mineralocorticoid).
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Ethacrynic Acid
- Warfarin
- Furosemide
- Torsemide
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Fludrocortisone
- Furosemide
- Aspirin
- Rifampin
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.