Cimetidine and Alprazolam Interaction
Drug interaction information between Cimetidine and Alprazolam.
Cimetidine and Alprazolam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cimetidine and Alprazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine can change how your body breaks down alprazolam, which can change the amount of medicine in your blood.
FDA Label Information
Examples Nefazodone, fluvoxamine, cimetidine, erythromycin CYP3A Inducers Clinical implication Concomitant use of CYP3A inducers can increase alprazolam metabolism and therefore can decease plasma levels of alprazolam [see Clinical Pharmacology (12.3) ] .
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Frequently Asked Questions
What SPL severity band is on file for Cimetidine + Alprazolam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Alprazolam's 27. In the minor band specifically: Cimetidine has 63 (also Albendazole, Alogliptin, Alosetron, Amiodarone); Alprazolam has 20 (also Tramadol, Oxycodone, Morphine, Carbamazepine).
What mechanism field is on file for Cimetidine and Alprazolam?
Cimetidine can change how your body breaks down alprazolam, which can change the amount of medicine in your blood.
Cimetidine carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is minor · classes on file: Cimetidine (H2 Receptor Antagonist); Alprazolam (Benzodiazepine).
Cimetidine has 4 major-labeled pairs vs Alprazolam's 0. This page itself is in the minor band, not the major band.
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alogliptin
- Alosetron
- Amiodarone
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Tramadol
- Oxycodone
- Morphine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.