Cimetidine and Amiodarone Interaction
Drug interaction information between Cimetidine and Amiodarone.
Cimetidine and Amiodarone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cimetidine and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine blocks the enzymes that break down amiodarone in your body. This causes the levels of amiodarone in your blood to rise, which could increase the risk of side effects.
FDA Label Information
Pharmacokinetic Interactions CYP450 Inhibitors grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine, certain protease inhibitors Increased exposure of amiodarone.
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Cimetidine + Amiodarone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Amiodarone's 42. In the minor band specifically: Cimetidine has 63 (also Albendazole, Alogliptin, Alosetron, Alprazolam); Amiodarone has 29 (also Atorvastatin, Clonidine, Diltiazem, Verapamil).
What mechanism field is on file for Cimetidine and Amiodarone?
Cimetidine blocks the enzymes that break down amiodarone in your body. This causes the levels of amiodarone in your blood to rise, which could increase the risk of side effects.
Cimetidine's labeled portfolio outnumbers Amiodarone
SPL source-record counts only. This page's band is minor · classes on file: Cimetidine (H2 Receptor Antagonist); Amiodarone (Class III Antiarrhythmic).
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alogliptin
- Alosetron
- Alprazolam
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Atorvastatin
- Clonidine
- Diltiazem
- Verapamil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.