Cimetidine and Levofloxacin Interaction
Drug interaction information between Cimetidine and Levofloxacin.
Cimetidine and Levofloxacin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Cimetidine and Levofloxacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine makes it harder for the kidneys to clear levofloxacin, causing the antibiotic to stay in the body slightly longer.
FDA Label Information
7.8 Probenecid and Cimetidine No significant effect of probenecid or cimetidine on the Cmax of levofloxacin was observed in a clinical study involving healthy volunteers. The AUC and t 1/2 of levofloxacin were higher while CL/F and CLR were lower during concomitant treatment of levofloxacin with probenecid or cimetidine compared to levofloxacin alone. However, these changes do not warrant dosage adjustment for levofloxacin when probenecid or cimetidine is co-administered.
Cimetidine Also Interacts With
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
Levofloxacin Also Interacts With
- Probenecid major
- Theophylline moderate
- Warfarin minor
- Cyclosporine minor
- Digoxin minor
Frequently Asked Questions
What SPL severity band is on file for Cimetidine + Levofloxacin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Levofloxacin's 8. In the major band specifically: Cimetidine has 4 (also Posaconazole, Risperidone, Valproate); Levofloxacin has 2 (also Probenecid).
What mechanism field is on file for Cimetidine and Levofloxacin?
Cimetidine makes it harder for the kidneys to clear levofloxacin, causing the antibiotic to stay in the body slightly longer.
Cimetidine carries more major-labeled pairs than Levofloxacin
SPL source-record counts only. This page's band is major · classes on file: Cimetidine (H2 Receptor Antagonist); Levofloxacin (Fluoroquinolone Antibiotic).
Cimetidine has 4 major-labeled pairs vs Levofloxacin's 2.
4 major · 10 moderate · 63 minor · 77 total
- Other major peers for Cimetidine
- Posaconazole
- Risperidone
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.