Cimetidine and Alogliptin Interaction
Drug interaction information between Cimetidine and Alogliptin.
Cimetidine and Alogliptin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cimetidine and Alogliptin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine can slow down how the body removes the medication, which may lead to the drug building up in your system.
FDA Label Information
( 7 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine), may increase the accumulation of metformin. Examples: Ranolazine, vandetanib, dolutegravir, and cimetidine Alcohol Clinical Impact: Alcohol is known to potentiate the effect of metformin on lactate metabolism.
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Alogliptin Also Interacts With
- Topiramate moderate
- Zonisamide moderate
- Metformin minor
- Dolutegravir minor
- Ranolazine minor
Frequently Asked Questions
What SPL severity band is on file for Cimetidine + Alogliptin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Alogliptin's 7. In the minor band specifically: Cimetidine has 63 (also Albendazole, Alosetron, Alprazolam, Amiodarone); Alogliptin has 5 (also Metformin, Dolutegravir, Ranolazine, Phenytoin).
What mechanism field is on file for Cimetidine and Alogliptin?
Cimetidine can slow down how the body removes the medication, which may lead to the drug building up in your system.
Cimetidine carries more major-labeled pairs than Alogliptin
SPL source-record counts only. This page's band is minor · classes on file: Cimetidine (H2 Receptor Antagonist); Alogliptin (DPP-4 Inhibitor).
Cimetidine has 4 major-labeled pairs vs Alogliptin's 0. This page itself is in the minor band, not the major band.
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alosetron
- Alprazolam
- Amiodarone
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Alogliptin
- Metformin
- Dolutegravir
- Ranolazine
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.