Cimetidine and Alosetron Interaction
Drug interaction information between Cimetidine and Alosetron.
Cimetidine and Alosetron have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cimetidine and Alosetron. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine may block the body from breaking down alosetron, which could lead to higher drug levels in your system.
FDA Label Information
Concomitant administration of alosetron and moderate CYP1A2 inhibitors, including quinolone antibiotics and cimetidine, has not been evaluated, but should be avoided unless clinically necessary because of similar potential drug interactions.
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Alosetron Also Interacts With
- Clarithromycin moderate
- Itraconazole moderate
- Voriconazole moderate
- Estradiol minor
- Hydralazine minor
Frequently Asked Questions
What SPL severity band is on file for Cimetidine + Alosetron?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Alosetron's 12. In the minor band specifically: Cimetidine has 63 (also Albendazole, Alogliptin, Alprazolam, Amiodarone); Alosetron has 9 (also Estradiol, Hydralazine, Ketoconazole, Theophylline).
What mechanism field is on file for Cimetidine and Alosetron?
Cimetidine may block the body from breaking down alosetron, which could lead to higher drug levels in your system.
Cimetidine carries more major-labeled pairs than Alosetron
SPL source-record counts only. This page's band is minor · classes on file: Cimetidine (H2 Receptor Antagonist); Alosetron (5-HT3 Antagonist (IBS-D)).
Cimetidine has 4 major-labeled pairs vs Alosetron's 0. This page itself is in the minor band, not the major band.
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alogliptin
- Alprazolam
- Amiodarone
0 major · 3 moderate · 9 minor · 12 total
- Other minor peers for Alosetron
- Estradiol
- Hydralazine
- Ketoconazole
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.