Cimetidine and Posaconazole Interaction
Drug interaction information between Cimetidine and Posaconazole.
Cimetidine and Posaconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Cimetidine and Posaconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine changes the environment in the stomach, which can prevent the body from absorbing enough posaconazole into the bloodstream.
FDA Label Information
Interaction Drug Interaction Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole* Avoid coadministration unless the benefit outweighs the risks ( 7.6 , 7.7 , 7.8 , 7.9 ) Other drugs metabolized by CYP3A4 Consider dosage adjustment and monitor for adverse effects and toxicity ( 7.1 , 7.10 , 7.11 ) Digoxin Monitor digoxin plasma concentrations ( 7.12 ) Fosamprenavir, metoclopramide* Monitor for breakthrough fungal infections ( 7.6 , 7.13 ) *The drug interactions with esomeprazole and metoclopramide do not apply to posaconazole tablets.
Cimetidine Also Interacts With
- Levofloxacin major
- Risperidone major
- Valproate major
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Metoclopramide major
- Phenytoin major
- Efavirenz/Emtricitabine/Tenofovir moderate
Frequently Asked Questions
What SPL severity band is on file for Cimetidine + Posaconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Posaconazole's 27. In the major band specifically: Cimetidine has 4 (also Levofloxacin, Risperidone, Valproate); Posaconazole has 5 (also Esomeprazole, Digoxin, Metoclopramide, Phenytoin).
What mechanism field is on file for Cimetidine and Posaconazole?
Cimetidine changes the environment in the stomach, which can prevent the body from absorbing enough posaconazole into the bloodstream.
Posaconazole carries more major-labeled pairs than Cimetidine
SPL source-record counts only. This page's band is major · classes on file: Cimetidine (H2 Receptor Antagonist); Posaconazole (Azole Antifungal).
Posaconazole has 5 major-labeled pairs vs Cimetidine's 4.
4 major · 10 moderate · 63 minor · 77 total
- Other major peers for Cimetidine
- Levofloxacin
- Risperidone
- Valproate
5 major · 5 moderate · 17 minor · 27 total
- Other major peers for Posaconazole
- Esomeprazole
- Digoxin
- Metoclopramide
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.