What the FDA labels say about taking them together
Ketorolac and probenecid
Ketorolac's FDA label of August 31, 2023 names probenecid in its contraindications section; the probenecid label PlainMeds reads does not name ketorolac. The ketorolac label: “Concomitant administration of oral ketorolac and probenecid results in increased half-life and systemic exposure. [ see Clinical Pharmacology ].”
Check it at the source: the ketorolac FDA label on DailyMed (effective August 31, 2023, Fresenius Kabi USA, LLC); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the ketorolac label say about probenecid?
Ketorolac label, contraindicationsThe concomitant use of ketorolac tromethamine and probenecid is contraindicated.
Sprix label (Zyla Life Sciences US LLC, December 5, 2024), contraindicationsThrough its prostaglandin synthesis inhibitory effect, ketorolac may adversely affect fetal circulation and inhibit uterine contractions, thus increasing the risk of uterine hemorrhage [ see Use in Specific Populations ( 8.1 ) ] Use in patients with suspected or confirmed cerebrovascular bleeding, hemorrhagic diathesis, incomplete hemostasis, or those for whom hemostasis is critical [ see Warnings and Precautions ( 5.11 ), Drug Interactions ( 7 ) ] Concomitant use with probenecid [ see Drug Interactions ( 7 ) ] Concomitant use with pentoxifylline [ see Drug Interactions ( 7 ) ] Known hypersensitivity to ketorolac or any components of the drug product ( 4 ) History of asthma, urticaria, or …
Sprix label (Zyla Life Sciences US LLC, December 5, 2024), drug interactionsClinical Impact: Concomitant administration of oral ketorolac and probenecid results in increased half-life and systemic exposure. [ see Clinical Pharmacology ( 12.3 ) ]. Intervention: Concomitant use of SPRIX and probenecid is contraindicated.
Source: FDA drug label (Sprix, NDA022382), Zyla Life Sciences US LLC, effective December 5, 2024 (SPL set 97005a1c-167e-4676-bae7-e49b38c36f9e), via openFDA
Source: FDA drug label (Ketorolac Tromethamine), Fresenius Kabi USA, LLC, effective August 31, 2023 (SPL set 3d88cbe6-5230-47aa-80af-0c41283d1f00), via openFDA; the full label on DailyMed
What does the probenecid label say about ketorolac?
Probenecid's label (effective January 5, 2021) does not name ketorolac in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketorolac | Probenecid | |
|---|---|---|
| Labeled for | Pain | Gout |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.02 per mL 30 mg/mL vial | $0.636 per tablet 500 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once