Probenecid and Ketorolac Interaction
Drug interaction information between Probenecid and Ketorolac.
Probenecid and Ketorolac have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Probenecid and Ketorolac. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Probenecid slows down the body's ability to clear ketorolac, which leads to much higher and potentially unsafe levels of the drug in your system.
What To Do
These two medicines should not be used together.
FDA Label Information
Established and Other Potentially Clinically Significant Drug Interactions Concomitant Drug/Drug Class Effect on Drug Concentration Recommendation Ketorolac tromethamine ↑ ketorolac tromethamine Contraindicated Ketoprofen ↑ ketoprofen Concomitant use is not recommended.
Probenecid Also Interacts With
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
- Cefuroxime moderate
Frequently Asked Questions
Can I take Probenecid and Ketorolac together?
This is a major interaction. These two medicines should not be used together.
How serious is the interaction between Probenecid and Ketorolac?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Probenecid and Ketorolac interact?
Probenecid slows down the body's ability to clear ketorolac, which leads to much higher and potentially unsafe levels of the drug in your system.
Understanding the Probenecid and Ketorolac Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Probenecid belongs to the Uricosuric Agent class and Ketorolac belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Probenecid slows down the body's ability to clear ketorolac, which leads to much higher and potentially unsafe levels of the drug in your system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Probenecid has 37 total documented interactions on file in this dataset, and Ketorolac has 3. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: These two medicines should not be used together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Probenecid or Ketorolac based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.