Probenecid and Cefazolin Interaction
Drug interaction information between Probenecid and Cefazolin.
Probenecid and Cefazolin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Probenecid and Cefazolin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid slows down how fast your kidneys remove cefazolin from your body, causing the antibiotic to stay in your blood longer.
FDA Label Information
Drug Interactions Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels.
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Probenecid + Cefazolin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Cefazolin's 1. In the minor band specifically: Probenecid has 23 (also Theophylline, Acetaminophen/Oxycodone, Ampicillin/Sulbactam, Carbidopa/Levodopa); Cefazolin has 1.
What mechanism field is on file for Probenecid and Cefazolin?
Probenecid slows down how fast your kidneys remove cefazolin from your body, causing the antibiotic to stay in your blood longer.
Probenecid carries more major-labeled pairs than Cefazolin
SPL source-record counts only. This page's band is minor · classes on file: Probenecid (Uricosuric Agent); Cefazolin (First-Generation Cephalosporin).
Probenecid has 2 major-labeled pairs vs Cefazolin's 0. This page itself is in the minor band, not the major band.
2 major · 12 moderate · 23 minor · 37 total
- Other minor peers for Probenecid
- Theophylline
- Acetaminophen/Oxycodone
- Ampicillin/Sulbactam
- Carbidopa/Levodopa
0 major · 0 moderate · 1 minor · 1 total
Cefazolin has no other minor-band peer in this dataset besides Probenecid.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.