Probenecid and Acetaminophen/Oxycodone Interaction
Drug interaction information between Probenecid and Acetaminophen/Oxycodone.
Probenecid and Acetaminophen/Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Probenecid and Acetaminophen/Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid can slow down how the body gets rid of acetaminophen, making it stay in your system a bit longer.
FDA Label Information
Probenecid Probenecid may increase the therapeutic effectiveness of acetaminophen slightly.
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
What SPL severity band is on file for Probenecid + Acetaminophen/Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Acetaminophen/Oxycodone's 23. In the minor band specifically: Probenecid has 23 (also Theophylline, Ampicillin/Sulbactam, Carbidopa/Levodopa, Cefazolin); Acetaminophen/Oxycodone has 21 (also Trazodone, Tramadol, Cyclobenzaprine, Oxycodone).
What mechanism field is on file for Probenecid and Acetaminophen/Oxycodone?
Probenecid can slow down how the body gets rid of acetaminophen, making it stay in your system a bit longer.
Probenecid carries more major-labeled pairs than Acetaminophen/Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Probenecid (Uricosuric Agent); Acetaminophen/Oxycodone (Opioid Analgesic Combination).
Probenecid has 2 major-labeled pairs vs Acetaminophen/Oxycodone's 0. This page itself is in the minor band, not the major band.
2 major · 12 moderate · 23 minor · 37 total
- Other minor peers for Probenecid
- Theophylline
- Ampicillin/Sulbactam
- Carbidopa/Levodopa
- Cefazolin
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.