Probenecid and Amoxicillin Interaction
Drug interaction information between Probenecid and Amoxicillin.
Probenecid and Amoxicillin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Probenecid and Amoxicillin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid blocks the kidneys from removing amoxicillin from the blood. This causes the antibiotic to stay in your body longer and reach higher levels than normal.
FDA Label Information
7 DRUG INTERACTIONS Co‑administration with probenecid is not recommended. ( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Co-administration of probenecid is not recommended.
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
- Cefuroxime moderate
Amoxicillin Also Interacts With
- Lansoprazole major
- Rabeprazole major
- Theophylline major
- Allopurinol moderate
- Estradiol minor
Frequently Asked Questions
What SPL severity band is on file for Probenecid + Amoxicillin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Amoxicillin's 12. In the moderate band specifically: Probenecid has 12 (also Amoxicillin/Clavulanate, Ceftazidime/Avibactam, Cefuroxime, Cephalexin); Amoxicillin has 2 (also Allopurinol).
What mechanism field is on file for Probenecid and Amoxicillin?
Probenecid blocks the kidneys from removing amoxicillin from the blood. This causes the antibiotic to stay in your body longer and reach higher levels than normal.
Amoxicillin carries more major-labeled pairs than Probenecid
SPL source-record counts only. This page's band is moderate · classes on file: Probenecid (Uricosuric Agent); Amoxicillin (Penicillin Antibiotic).
Amoxicillin has 3 major-labeled pairs vs Probenecid's 2. This page itself is in the moderate band, not the major band.
2 major · 12 moderate · 23 minor · 37 total
- Other moderate peers for Probenecid
- Amoxicillin/Clavulanate
- Ceftazidime/Avibactam
- Cefuroxime
- Cephalexin
3 major · 2 moderate · 7 minor · 12 total
- Other moderate peers for Amoxicillin
- Allopurinol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.