Probenecid and Theophylline Interaction
Drug interaction information between Probenecid and Theophylline.
Probenecid and Theophylline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Probenecid and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid can interfere with certain lab tests, making it look like there is more theophylline in your blood than there actually is.
FDA Label Information
Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid (a component of ORLYNVAH) were added to human plasma.
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Probenecid + Theophylline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Probenecid's 37. In the minor band specifically: Probenecid has 23 (also Acetaminophen/Oxycodone, Ampicillin/Sulbactam, Carbidopa/Levodopa, Cefazolin); Theophylline has 54 (also Propranolol, Methotrexate, Diazepam, Lithium).
What mechanism field is on file for Probenecid and Theophylline?
Probenecid can interfere with certain lab tests, making it look like there is more theophylline in your blood than there actually is.
Theophylline carries more major-labeled pairs than Probenecid
SPL source-record counts only. This page's band is minor · classes on file: Probenecid (Uricosuric Agent); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Probenecid's 2. This page itself is in the minor band, not the major band.
2 major · 12 moderate · 23 minor · 37 total
- Other minor peers for Probenecid
- Acetaminophen/Oxycodone
- Ampicillin/Sulbactam
- Carbidopa/Levodopa
- Cefazolin
27 major · 5 moderate · 54 minor · 86 total
- Other minor peers for Theophylline
- Propranolol
- Methotrexate
- Diazepam
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.