Bictegravir and Sertraline Interaction
Drug interaction information between Bictegravir and Sertraline.
Bictegravir and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bictegravir and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medications do not have any meaningful effect on how the other is processed by the body.
FDA Label Information
7.6 Drugs without Clinically Significant Interactions with BIKTARVY Based on drug interaction studies conducted with BIKTARVY or the components of BIKTARVY, no clinically significant drug interactions have been observed when BIKTARVY is combined with the following drugs: ethinyl estradiol, ledipasvir/sofosbuvir, midazolam, norgestimate, sertraline, sofosbuvir, sofosbuvir/velpatasvir, and sofosbuvir/velpatasvir/voxilaprevir.
Bictegravir Also Interacts With
- Rifampin major
- Dofetilide major
- Metformin moderate
- Estradiol minor
- Valacyclovir minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
What SPL severity band is on file for Bictegravir/Emtricitabine/Tenofovir + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Bictegravir's 19. In the minor band specifically: Bictegravir has 16 (also Estradiol, Valacyclovir, Acyclovir, Carbamazepine); Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol).
What mechanism field is on file for Bictegravir/Emtricitabine/Tenofovir and Sertraline?
These two medications do not have any meaningful effect on how the other is processed by the body.
Bictegravir carries more major-labeled pairs than Sertraline
SPL source-record counts only. This page's band is minor · classes on file: Bictegravir (Integrase Inhibitor / NRTI Combination); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Bictegravir has 2 major-labeled pairs vs Sertraline's 1. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 16 minor · 19 total
- Other minor peers for Bictegravir
- Estradiol
- Valacyclovir
- Acyclovir
- Carbamazepine
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.