Bictegravir and Estradiol Interaction
Drug interaction information between Bictegravir and Estradiol.
Bictegravir and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bictegravir and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clinical studies show that these drugs do not interfere with each other when taken at the same time.
FDA Label Information
7.6 Drugs without Clinically Significant Interactions with BIKTARVY Based on drug interaction studies conducted with BIKTARVY or the components of BIKTARVY, no clinically significant drug interactions have been observed when BIKTARVY is combined with the following drugs: ethinyl estradiol, ledipasvir/sofosbuvir, midazolam, norgestimate, sertraline, sofosbuvir, sofosbuvir/velpatasvir, and sofosbuvir/velpatasvir/voxilaprevir.
Bictegravir Also Interacts With
- Rifampin major
- Dofetilide major
- Metformin moderate
- Sertraline minor
- Valacyclovir minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Bictegravir/Emtricitabine/Tenofovir + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Bictegravir's 19. In the minor band specifically: Bictegravir has 16 (also Sertraline, Valacyclovir, Acyclovir, Carbamazepine); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Bictegravir/Emtricitabine/Tenofovir and Estradiol?
Clinical studies show that these drugs do not interfere with each other when taken at the same time.
Bictegravir carries more major-labeled pairs than Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Bictegravir (Integrase Inhibitor / NRTI Combination); Estradiol (Estrogen Hormone).
Bictegravir has 2 major-labeled pairs vs Estradiol's 1. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 16 minor · 19 total
- Other minor peers for Bictegravir
- Sertraline
- Valacyclovir
- Acyclovir
- Carbamazepine
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.