Bictegravir and Carbamazepine Interaction
Drug interaction information between Bictegravir and Carbamazepine.
Bictegravir and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bictegravir and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine can speed up the body's breakdown of the HIV medication, which may make the treatment less effective.
FDA Label Information
Anticonvulsants: carbamazepine Drug-drug interaction study was conducted with either BIKTARVY or its components as individual agents.
Bictegravir Also Interacts With
- Rifampin major
- Dofetilide major
- Metformin moderate
- Sertraline minor
- Estradiol minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Bictegravir/Emtricitabine/Tenofovir + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Bictegravir's 19. In the minor band specifically: Bictegravir has 16 (also Sertraline, Estradiol, Valacyclovir, Acyclovir); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Bictegravir/Emtricitabine/Tenofovir and Carbamazepine?
Carbamazepine can speed up the body's breakdown of the HIV medication, which may make the treatment less effective.
Carbamazepine carries more major-labeled pairs than Bictegravir
SPL source-record counts only. This page's band is minor · classes on file: Bictegravir (Integrase Inhibitor / NRTI Combination); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Bictegravir's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 16 minor · 19 total
- Other minor peers for Bictegravir
- Sertraline
- Estradiol
- Valacyclovir
- Acyclovir
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.