Bictegravir and Rifampin Interaction
Drug interaction information between Bictegravir and Rifampin.
Bictegravir and Rifampin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Bictegravir and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up how fast your body breaks down the HIV medicine, which makes the HIV medicine less effective. This can cause the HIV virus to become harder to treat.
FDA Label Information
Antimycobacterials: rifabutin rifampin , Strong inducer of CYP3Aand P-gp, and inducer of UGT1A1. rifapentine ↓ BIC ↓ TAF Coadministration with rifampin is contraindicated due to the effect of rifampin on the BIC component of BIKTARVY [see Contraindications (4) ] .
Bictegravir Also Interacts With
- Dofetilide major
- Metformin moderate
- Sertraline minor
- Estradiol minor
- Valacyclovir minor
Rifampin Also Interacts With
- Darunavir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
- Ranolazine major
Frequently Asked Questions
What SPL severity band is on file for Bictegravir/Emtricitabine/Tenofovir + Rifampin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Bictegravir's 19. In the major band specifically: Bictegravir has 2 (also Dofetilide); Rifampin has 8 (also Darunavir, Glecaprevir/Pibrentasvir, Nirmatrelvir/Ritonavir, Pitavastatin).
What mechanism field is on file for Bictegravir/Emtricitabine/Tenofovir and Rifampin?
Rifampin speeds up how fast your body breaks down the HIV medicine, which makes the HIV medicine less effective. This can cause the HIV virus to become harder to treat.
Rifampin carries more major-labeled pairs than Bictegravir
SPL source-record counts only. This page's band is major · classes on file: Bictegravir (Integrase Inhibitor / NRTI Combination); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Bictegravir's 2.
8 major · 26 moderate · 103 minor · 137 total
- Other major peers for Rifampin
- Darunavir
- Glecaprevir/Pibrentasvir
- Nirmatrelvir/Ritonavir
- Pitavastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.