What the FDA labels say about taking them together
Bictegravir/emtricitabine/tenofovir alafenamide and metformin
Bictegravir/emtricitabine/tenofovir alafenamide's FDA label of April 30, 2024 names metformin in its drug interactions section; the metformin labels PlainMeds reads (3) do not name bictegravir/emtricitabine/tenofovir alafenamide. The bictegravir/emtricitabine/tenofovir alafenamide label: “Refer to the prescribing information of metformin for assessing the benefit and risk of concomitant use of BIKTARVY and metformin.”
Check it at the source: the bictegravir/emtricitabine/tenofovir alafenamide FDA label on DailyMed (effective April 30, 2024, A-S Medication Solutions); the metformin FDA label on DailyMed (effective September 3, 2026, Granules India Ltd).
What does the bictegravir/emtricitabine/tenofovir alafenamide label say about metformin?
Bictegravir/emtricitabine/tenofovir alafenamide label, drug interactionsConcomitant Drug Class/Drug Name: Metformin; Effect on Concentration ↑ = Increase, ↓ = Decrease.: ↑ Metformin; Clinical Comment: Refer to the prescribing information of metformin for assessing the benefit and risk of concomitant use of BIKTARVY and metformin.
Source: FDA drug label (Biktarvy), NDA210251 (Gilead Sciences Inc), as published by A-S Medication Solutions, effective April 30, 2024 (SPL set 0476d7eb-1024-4821-bbe7-abaacfda32a2), via openFDA; the full label on DailyMed
What does the metformin label say about bictegravir/emtricitabine/tenofovir alafenamide?
Metformin's label (effective September 3, 2026) and its 2 other brand-application labels do not name bictegravir/emtricitabine/tenofovir alafenamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (METFORMIN HYDROCHLORIDE), Granules India Ltd, effective September 3, 2026 (SPL set 73197cb5-3e23-4ac0-b189-f9bc848bce66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bictegravir/emtricitabine/tenofovir alafenamide | Metformin | |
|---|---|---|
| Labeled for | HIV | Type 2 diabetes |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $136.73 per tablet 50-200-25 mg tablet | $0.0145 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once