Bictegravir and Acyclovir Interaction
Drug interaction information between Bictegravir and Acyclovir.
Bictegravir and Acyclovir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bictegravir and Acyclovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications leave the body through the same kidney filters, which could lead to a buildup of the drugs in your system.
FDA Label Information
Some examples of drugs that are eliminated by active tubular secretion include, but are not limited to, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see Warnings and Precautions (5.4) ] .
Bictegravir Also Interacts With
- Rifampin major
- Dofetilide major
- Metformin moderate
- Sertraline minor
- Estradiol minor
Acyclovir Also Interacts With
- Cidofovir minor
- Emtricitabine/Tenofovir minor
- Meperidine minor
- Tenofovir Disoproxil minor
- Tizanidine minor
Frequently Asked Questions
What SPL severity band is on file for Bictegravir/Emtricitabine/Tenofovir + Acyclovir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bictegravir has 19 labeled pairs on file vs Acyclovir's 7. In the minor band specifically: Bictegravir has 16 (also Sertraline, Estradiol, Valacyclovir, Carbamazepine); Acyclovir has 7 (also Cidofovir, Emtricitabine/Tenofovir, Meperidine, Tenofovir Disoproxil).
What mechanism field is on file for Bictegravir/Emtricitabine/Tenofovir and Acyclovir?
These medications leave the body through the same kidney filters, which could lead to a buildup of the drugs in your system.
Bictegravir carries more major-labeled pairs than Acyclovir
SPL source-record counts only. This page's band is minor · classes on file: Bictegravir (Integrase Inhibitor / NRTI Combination); Acyclovir (Antiviral (Nucleoside Analog)).
Bictegravir has 2 major-labeled pairs vs Acyclovir's 0. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 16 minor · 19 total
- Other minor peers for Bictegravir
- Sertraline
- Estradiol
- Valacyclovir
- Carbamazepine
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Acyclovir
- Cidofovir
- Emtricitabine/Tenofovir
- Meperidine
- Tenofovir Disoproxil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.