Bictegravir and Dofetilide Interaction
Drug interaction information between Bictegravir and Dofetilide.
Bictegravir and Dofetilide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Bictegravir and Dofetilide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The HIV medicine blocks the way your body removes the heart medicine dofetilide, causing it to build up to dangerous levels. High levels of dofetilide can cause life-threatening heart rhythm problems.
FDA Label Information
Coadministration of BIKTARVY with drugs that are substrates of OCT2 and MATE1 (e.g., dofetilide) may increase their plasma concentrations (see Table 3 ). Clinical Comment Antiarrhythmics: dofetilide ↑ Dofetilide Coadministration is contraindicated due to the potential for serious and/or life-threatening events associated with dofetilide therapy [see Contraindications (4) ] .
Bictegravir Also Interacts With
- Rifampin major
- Metformin moderate
- Sertraline minor
- Estradiol minor
- Valacyclovir minor
Dofetilide Also Interacts With
- Dolutegravir major
- Dolutegravir/Lamivudine major
- Itraconazole major
- Clarithromycin moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Bictegravir/Emtricitabine/Tenofovir + Dofetilide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bictegravir has 19 labeled pairs on file vs Dofetilide's 8. In the major band specifically: Bictegravir has 2 (also Rifampin); Dofetilide has 4 (also Dolutegravir, Dolutegravir/Lamivudine, Itraconazole).
What mechanism field is on file for Bictegravir/Emtricitabine/Tenofovir and Dofetilide?
The HIV medicine blocks the way your body removes the heart medicine dofetilide, causing it to build up to dangerous levels. High levels of dofetilide can cause life-threatening heart rhythm problems.
Dofetilide carries more major-labeled pairs than Bictegravir
SPL source-record counts only. This page's band is major · classes on file: Bictegravir (Integrase Inhibitor / NRTI Combination); Dofetilide (Class III Antiarrhythmic).
Dofetilide has 4 major-labeled pairs vs Bictegravir's 2.
4 major · 3 moderate · 1 minor · 8 total
- Other major peers for Dofetilide
- Dolutegravir
- Dolutegravir/Lamivudine
- Itraconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.