Estradiol and Topiramate Interaction
Drug interaction information between Estradiol and Topiramate.
Estradiol and Topiramate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Estradiol and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Topiramate speeds up the breakdown of estradiol in your body. This can lower the amount of hormone in your blood and make it less effective.
FDA Label Information
Examples Aprepitant, barbiturates, bosentan, carbamazepine, efavirenz, felbamate, griseofulvin, oxcarbazepine, phenytoin, rifampin, rifabutin, rufinamide, topiramate, products containing St.
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Estradiol + Topiramate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Topiramate's 30. In the minor band specifically: Estradiol has 50 (also Rosuvastatin, Lamotrigine, Tizanidine, Acetaminophen); Topiramate has 27 (also Hydrochlorothiazide, Amitriptyline, Pioglitazone, Carbamazepine).
What mechanism field is on file for Estradiol and Topiramate?
Topiramate speeds up the breakdown of estradiol in your body. This can lower the amount of hormone in your blood and make it less effective.
Estradiol carries more major-labeled pairs than Topiramate
SPL source-record counts only. This page's band is minor · classes on file: Estradiol (Estrogen Hormone); Topiramate (Anticonvulsant).
Estradiol has 1 major-labeled pair vs Topiramate's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Tizanidine
- Acetaminophen
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Hydrochlorothiazide
- Amitriptyline
- Pioglitazone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.