Estradiol and Rosuvastatin Interaction
Drug interaction information between Estradiol and Rosuvastatin.
Estradiol and Rosuvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Estradiol and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rosuvastatin can increase the amount of estrogen that stays in your body.
FDA Label Information
Substances increasing the systemic exposure of COCs: Co-administration of atorvastatin or rosuvastatin and certain COCs containing ethinyl estradiol (EE) increase AUC values for EE by approximately 20 to 25%.
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Lamotrigine minor
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Frequently Asked Questions
What SPL severity band is on file for Estradiol + Rosuvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Rosuvastatin's 21. In the minor band specifically: Estradiol has 50 (also Lamotrigine, Topiramate, Tizanidine, Acetaminophen); Rosuvastatin has 10 (also Fenofibrate, Warfarin, Brexpiprazole, Darunavir).
What mechanism field is on file for Estradiol and Rosuvastatin?
Rosuvastatin can increase the amount of estrogen that stays in your body.
Rosuvastatin carries more major-labeled pairs than Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Estradiol (Estrogen Hormone); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Rosuvastatin has 3 major-labeled pairs vs Estradiol's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Lamotrigine
- Topiramate
- Tizanidine
- Acetaminophen
3 major · 8 moderate · 10 minor · 21 total
- Other minor peers for Rosuvastatin
- Fenofibrate
- Warfarin
- Brexpiprazole
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.