What the FDA labels say about taking them together
Estradiol and tizanidine
Neither FDA label names the other in its interaction, contraindication or warning sections. A label lists the interactions its studies and reports found; it is not a complete list, so ask a pharmacist before combining medicines. Labels read October 8, 2026.
Check it at the source: the estradiol FDA label on DailyMed (effective April 3, 2024, Amneal Pharmaceuticals LLC); the tizanidine FDA label on DailyMed (effective January 2, 2026, Legacy Pharma USA, Inc.).
What does the estradiol label say about tizanidine?
Estradiol's label (effective April 3, 2024) and its 3 other brand-application labels do not name tizanidine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (YUVAFEM), Amneal Pharmaceuticals LLC, effective April 3, 2024 (SPL set 30c7f6ba-7a9e-4853-b3e4-e00a46560224), via openFDA; the full label on DailyMed
What does the tizanidine label say about estradiol?
Tizanidine's label (effective January 2, 2026) and its 2 other brand-application labels do not name estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zanaflex), Legacy Pharma USA, Inc., effective January 2, 2026 (SPL set 60c27d35-7349-4fc6-86ad-70fffdbe3e08), via openFDA; the full label on DailyMed
A pharmacist or prescriber can say whether these two medicines suit one person together; PlainMeds does not grade interactions.
Both medicines on the record
| Estradiol | Tizanidine | |
|---|---|---|
| Labeled for | Menopause symptoms, Breast cancer, Osteoporosis | Muscle spasms and spasticity |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0635 per tablet 1 mg tablet | $0.0331 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once