Estradiol and Tizanidine Interaction
Drug interaction information between Estradiol and Tizanidine.
Estradiol and Tizanidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Estradiol and Tizanidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Estradiol can stop your body from breaking down tizanidine as fast as it should. This can cause the tizanidine levels to build up in your blood.
FDA Label Information
Concomitant use with ethinyl estradiol-containing COCs may increase systemic exposure of other drugs (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole).
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Tizanidine Also Interacts With
- Ciprofloxacin major
- Fluvoxamine major
- Famotidine moderate
- Acyclovir minor
- Verapamil minor
Frequently Asked Questions
What SPL severity band is on file for Estradiol + Tizanidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Tizanidine's 17. In the minor band specifically: Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Acetaminophen); Tizanidine has 14 (also Acyclovir, Verapamil, Amiodarone, Propafenone).
What mechanism field is on file for Estradiol and Tizanidine?
Estradiol can stop your body from breaking down tizanidine as fast as it should. This can cause the tizanidine levels to build up in your blood.
Tizanidine carries more major-labeled pairs than Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Estradiol (Estrogen Hormone); Tizanidine (Central Alpha-2 Agonist (Muscle Relaxant)).
Tizanidine has 2 major-labeled pairs vs Estradiol's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Acetaminophen
2 major · 1 moderate · 14 minor · 17 total
- Other minor peers for Tizanidine
- Acyclovir
- Verapamil
- Amiodarone
- Propafenone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.