Estradiol and Etonogestrel Interaction
Drug interaction information between Estradiol and Etonogestrel.
Estradiol and Etonogestrel have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Estradiol and Etonogestrel. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Certain medications can speed up how the body breaks down birth control hormones. This makes the birth control less effective and increases the risk of pregnancy.
FDA Label Information
Counsel women to use an alternative non-hormonal method of contraception or a back-up method when enzyme inducers are used with Etonogestrel and ethinyl estradiol vaginal ring, and to continue back-up non-hormonal contraception for 28 days after discontinuing the enzyme inducer to ensure contraceptive reliability. Note: Etonogestrel and ethinyl estradiol vaginal ring may interfere with the correct placement and position of certain female barrier methods such as a diaphragm or female condom. These methods are not recommended as back-up methods with Etonogestrel and ethinyl estradiol vaginal...
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
- Lamotrigine minor
Etonogestrel Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Amoxicillin minor
- Lamotrigine minor
- Topiramate minor
Frequently Asked Questions
What SPL severity band is on file for Estradiol + Etonogestrel?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Etonogestrel's 29. In the moderate band specifically: Estradiol has 3 (also Glecaprevir/Pibrentasvir, Tacrolimus Topical); Etonogestrel has 2 (also Glecaprevir/Pibrentasvir).
What mechanism field is on file for Estradiol and Etonogestrel?
Certain medications can speed up how the body breaks down birth control hormones. This makes the birth control less effective and increases the risk of pregnancy.
Estradiol carries more major-labeled pairs than Etonogestrel
SPL source-record counts only. This page's band is moderate · classes on file: Estradiol (Estrogen Hormone); Etonogestrel (Progestin (Implant)).
Estradiol has 1 major-labeled pair vs Etonogestrel's 0. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 50 minor · 54 total
- Other moderate peers for Estradiol
- Glecaprevir/Pibrentasvir
- Tacrolimus Topical
0 major · 2 moderate · 27 minor · 29 total
- Other moderate peers for Etonogestrel
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.