Estradiol and Lamotrigine Interaction
Drug interaction information between Estradiol and Lamotrigine.
Estradiol and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Estradiol and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Estradiol makes your body get rid of lamotrigine more quickly. This can lower the amount of medicine in your blood and might lead to more seizures.
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Estradiol + Lamotrigine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Lamotrigine's 24. In the minor band specifically: Estradiol has 50 (also Rosuvastatin, Topiramate, Tizanidine, Acetaminophen); Lamotrigine has 22 (also Valproate, Carbamazepine, Rifampin, Phenytoin).
What mechanism field is on file for Estradiol and Lamotrigine?
Estradiol makes your body get rid of lamotrigine more quickly. This can lower the amount of medicine in your blood and might lead to more seizures.
Estradiol carries more major-labeled pairs than Lamotrigine
SPL source-record counts only. This page's band is minor · classes on file: Estradiol (Estrogen Hormone); Lamotrigine (Anticonvulsant).
Estradiol has 1 major-labeled pair vs Lamotrigine's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Topiramate
- Tizanidine
- Acetaminophen
0 major · 2 moderate · 22 minor · 24 total
- Other minor peers for Lamotrigine
- Valproate
- Carbamazepine
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.