Asenapine and Paroxetine Interaction
Drug interaction information between Asenapine and Paroxetine.
Asenapine and Paroxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Asenapine and Paroxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Asenapine slows down the process your body uses to get rid of paroxetine, which can double the amount of paroxetine in your blood.
FDA Label Information
( 5.7 , 7.1 , 12.3 ) • Paroxetine (CYP2D6 substrate and inhibitor): Reduce paroxetine by half when used in combination with asenapine. CYP2D6 substrates and inhibitors (e.g., paroxetine) Asenapine may enhance the inhibitory effects of paroxetine on its own metabolism. Concomitant use of paroxetine with asenapine increased the paroxetine exposure by 2-fold as compared to use paroxetine alone [see Clinical Pharmacology (12.3)].
Asenapine Also Interacts With
- Carbamazepine minor
- Lithium minor
- Rifampin minor
- Imipramine minor
- Fluvoxamine minor
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Asenapine + Paroxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Asenapine's 8. In the minor band specifically: Asenapine has 8 (also Carbamazepine, Lithium, Rifampin, Imipramine); Paroxetine has 44 (also Buspirone, Clopidogrel, Aspirin, Venlafaxine).
What mechanism field is on file for Asenapine and Paroxetine?
Asenapine slows down the process your body uses to get rid of paroxetine, which can double the amount of paroxetine in your blood.
Paroxetine carries more major-labeled pairs than Asenapine
SPL source-record counts only. This page's band is minor · classes on file: Asenapine (Atypical Antipsychotic); Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Paroxetine has 3 major-labeled pairs vs Asenapine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Asenapine
- Carbamazepine
- Lithium
- Rifampin
- Imipramine
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Aspirin
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.