What the FDA labels say about taking them together
Asenapine and fluvoxamine
Asenapine's FDA label of January 31, 2025 names fluvoxamine in its drug interactions section; the fluvoxamine labels PlainMeds reads (2) do not name asenapine.
Check it at the source: the asenapine FDA label on DailyMed (effective January 31, 2025, Allergan, Inc.); the fluvoxamine FDA label on DailyMed (effective June 27, 2026, Zydus Pharmaceuticals USA Inc.).
What does the asenapine label say about fluvoxamine?
Asenapine label, drug interactionsStrong CYP1A2 Inhibitors (e.g., Fluvoxamine) SAPHRIS is metabolized by CYP1A2.
Secuado label (Noven Therapeutics, LLC, January 30, 2025), drug interactionsFluvoxamine, ciprofloxacin, enoxacin CYP2D6 substrates and inhibitors Clinical Implication Asenapine may enhance the inhibitory effects of paroxetine on its own metabolism by CYP2D6.
Source: FDA drug label (Secuado, NDA212268), Noven Therapeutics, LLC, effective January 30, 2025 (SPL set 685eaf44-5944-4f38-afba-0a4fc0b3462b), via openFDA
Source: FDA drug label (SAPHRIS), NDA022117 (Abbvie), as published by Allergan, Inc., effective January 31, 2025 (SPL set 5429f134-839f-4ffc-9944-55f51238def8), via openFDA; the full label on DailyMed
What does the fluvoxamine label say about asenapine?
Fluvoxamine's label (effective June 27, 2026) and its 1 other brand-application label do not name asenapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fluvoxamine maleate extended-release), Zydus Pharmaceuticals USA Inc., effective June 27, 2026 (SPL set 6c71d4f6-54b5-4d3a-8d2f-b7773c92c32e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Asenapine | Fluvoxamine | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $2.63 per tablet 10 mg tablet sl | $4.08 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once