Asenapine and Imipramine Interaction
Drug interaction information between Asenapine and Imipramine.
Asenapine and Imipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Asenapine and Imipramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications do not significantly change how the body processes or reacts to one another.
FDA Label Information
7.2 Drugs Having No Clinically Important Interactions with Asenapine No dosage adjustment of asenapine is necessary when administered concomitantly with paroxetine (see Table 12 in Drug Interactions (7.1) for paroxetine dosage adjustment), imipramine, cimetidine, valporate, lithium, or a CYP3A4 inducer (e.g., carbamazepine, phenytoin, rifampin).
Asenapine Also Interacts With
- Paroxetine minor
- Carbamazepine minor
- Lithium minor
- Rifampin minor
- Fluvoxamine minor
Imipramine Also Interacts With
- Epinephrine moderate
- Norepinephrine moderate
- Zolpidem moderate
- Sertraline minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Asenapine + Imipramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Imipramine has 20 labeled pairs on file vs Asenapine's 8. In the minor band specifically: Asenapine has 8 (also Paroxetine, Carbamazepine, Lithium, Rifampin); Imipramine has 17 (also Sertraline, Paroxetine, Flecainide, Propafenone).
What mechanism field is on file for Asenapine and Imipramine?
These medications do not significantly change how the body processes or reacts to one another.
Imipramine's labeled portfolio outnumbers Asenapine
SPL source-record counts only. This page's band is minor · classes on file: Asenapine (Atypical Antipsychotic); Imipramine (Tricyclic Antidepressant (TCA)).
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Asenapine
- Paroxetine
- Carbamazepine
- Lithium
- Rifampin
0 major · 3 moderate · 17 minor · 20 total
- Other minor peers for Imipramine
- Sertraline
- Paroxetine
- Flecainide
- Propafenone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.