Asenapine and Lithium Interaction
Drug interaction information between Asenapine and Lithium.
Asenapine and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Asenapine and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not have a meaningful effect on each other's levels in the blood.
FDA Label Information
7.2 Drugs Having No Clinically Important Interactions with Asenapine No dosage adjustment of asenapine is necessary when administered concomitantly with paroxetine (see Table 12 in Drug Interactions (7.1) for paroxetine dosage adjustment), imipramine, cimetidine, valporate, lithium, or a CYP3A4 inducer (e.g., carbamazepine, phenytoin, rifampin). In addition, valproic acid and lithium pre-dose serum concentrations collected from an adjunctive therapy study were comparable between asenapine-treated patients and placebo-treated patients indicating a lack of effect of asenapine on valproic and...
Asenapine Also Interacts With
- Paroxetine minor
- Carbamazepine minor
- Rifampin minor
- Imipramine minor
- Fluvoxamine minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Asenapine + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Asenapine's 8. In the minor band specifically: Asenapine has 8 (also Paroxetine, Carbamazepine, Rifampin, Imipramine); Lithium has 65 (also Aripiprazole, Canagliflozin, Candesartan, Celecoxib).
What mechanism field is on file for Asenapine and Lithium?
These two drugs do not have a meaningful effect on each other's levels in the blood.
Lithium carries more major-labeled pairs than Asenapine
SPL source-record counts only. This page's band is minor · classes on file: Asenapine (Atypical Antipsychotic); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Asenapine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Asenapine
- Paroxetine
- Carbamazepine
- Rifampin
- Imipramine
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Canagliflozin
- Candesartan
- Celecoxib
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.